Hello and Welcome to Windows7forums.. 
Yes, you certainly can use the Upgrade media to perform a clean install..
Please refer to this thread for the guide on how to perform a clean install using the Upgrade Media..
This is why you should never pay full price for an OS.. 
Info regarding Upgrade Media..
And yes, you will have to do a clean install.. Unfortunately you can't just "upgrade" from the RC or the RTM to the Final version...
Operating System Windows 7 Ultimate 64- Bit Edition
Computer Type Custom Build 6 of 6
CPU Type and Speed AMD Phenom II X4 965 (3.4GHZ) 4000MHz HT Quad-Core Socket AM3
Motherboard Chipset Asus Crosshair III Formula AMD 790FX Socket AM3
System Memory Type Corsair TR3X6G1600C8D Dominator - DDR3-1600:PC3 -12800 - 6GB - Non-ECC Unbuffered 240-Pin DIMM
Video Card Type and Speed Sapphire Radeon HD 5870 1GB PCI-Express (2.0)
Computer Monitor Samsung SyncMaster P2350 23" FULL 1080p HD LCD Monitor
Hard Drive (2) WD VelociRaptor 300GB 10000RPM 16MB Buffer: (2) WD Caviar 1.5TB "IntelliPower" 64MB Buffer
Optical Drives (2) LG 22x Super Multi Drives (SATA II) - Both with Lightscribe
Network Adapter Asus Crosshair III Formula Gigabit Ethernet Adapter
Anti-virus Software AVG Free Edition 9.0
Computer Skill Level Self-Taught Expert
Windows Experience Index 7.2